To evaluate anticonvulsant activities of ethanolic extract of Swertia chirata and aqueous extract Cinnamomum zeylanicum in MES and PTZ model. Adult male rats (275-325g) were given extracts of Swertia Chirata and Cinnamomum zeylanicum alone at three doses of 250, 500, 750 mg/kg, (p.o.) and combination of both extracts. Standard drug phenytoin sodium at 25 mg/kg, (i.p.). MES and PTZ model are used to test the anticonvulsant property of extract. In MES model duration of\r\nextensor phase and in PTZ model onset of action was observed and evaluated. The duration of hind limb extension in MES test was reduced by 75 % significantly (p<0.01) by Swertia Chirata and Cinnamomum zeylanicum at a dose level of 500 mg/kg. In PTZ group, the seizure latency was prolonged by Swertia Chirata and Cinnamomum zeylanicum at dose levels of 250, 500 mg/kg and 500, 750 mg/kg respectively. The lower dose (250 mg/kg) was found to be effective in case of Swertia chirata by 70% whereas the higher dose (500 mg/kg) did show 72% effectiveness. In case of Cinnamomum zeylanicum the lower dose (500 mg/kg) showed 53% effectiveness while the higher dose (750 mg/kg) was 85% in force. The present investigation demonstrated that Swertia chirata and Cinnamomum zeylanicum posses anticonvulsant activity
Loading....